Search results for "Developmental profile"

showing 4 items of 4 documents

Prenatal low-level exposure to CO alters postnatal development of hippocampal nitric oxide synthase and haem-oxygenase activities in rats.

2001

The effects of prenatal CO exposure (150 ppm from days 0 to 20 of pregnancy) on the postnatal development of hippocampal neuronal NO synthase (nNOS) and haem-oxygenase (HO-2) isoform activities in 15-, 30- and 90-d-old rats were investigated. Unlike HO-2, hippocampal nNOS activity increased from postnatal days 15-90 in controls. Prenatal CO produced a long-lasting decrease in either nNOS or HO-2. The results suggest that the altered developmental profile of hippocampal nNOS and HO-2 activities could be involved in cognitive deficits and long-term potentiation dysfunction exhibited by rats prenatally exposed to CO levels resulting in carboxyhaemoglobin (HbCO) levels equivalent to those obser…

Gene isoformmedicine.medical_specialtyNitric Oxide Synthase Type IHippocampal formationHippocampusCarbon monoxide; haem-oxygenase; hippocampus; nitric oxide synthase; prenatal exposure.HemoglobinsPregnancyInternal medicinemedicineAnimalsPharmacology (medical)Rats WistarPharmacologyDevelopmental profilePregnancyCarbon MonoxidebiologyChemistryLong-term potentiationLow level exposuremedicine.diseaseHaem OxygenaseRatsNitric oxide synthaseIsoenzymesPsychiatry and Mental healthEndocrinologyPrenatal Exposure Delayed EffectsHeme Oxygenase (Decyclizing)biology.proteinFemaleNitric Oxide SynthaseThe international journal of neuropsychopharmacology
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Infant developmental profile of Crisponi syndrome due to compound heterozygosity for CRLF1 deletion.

2020

Crisponi syndrome/CISS1, is an autosomal recessive ciliary neurotrophic factor receptor (CNTFR)-related genodermatosis caused in 95% of cases by mutations in CRLF1 on chromosome 19p13. The CNTFR pathway is important for CNS development. Crisponi syndrome/ CISS1 can be suspected in the presence of the following clinical triad: camptodactyly with fisted hands, intermittent hyperthermia and muscular contractions with feeding difficulties.

MalePathologymedicine.medical_specialtyCrisponi syndromeCompound heterozygosityPathology and Forensic MedicineCamptodactylyDeath SuddenPeriodic feverMedicineHumansHyperhidrosisReceptors CytokineGenetics (clinical)Sequence DeletionDevelopmental profiledevelopmental delay thin corpus callosum clinical profilebusiness.industryInfant NewbornFaciesInfantCold-induced sweating syndromeGeneral MedicineThin corpus callosumPediatrics Perinatology and Child HealthTrismusAnatomymedicine.symptomDevelopmental DelayCold-induced sweating syndrome CamptodactylyThin corpus callosum Periodic feverbusinessHand Deformities CongenitalClinical dysmorphology
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Developmental profiles of epidermal mRNAs during the pupal-adult molt of Tenebrio molitor and isolation of a cDNA clone encoding an adult cuticular p…

1992

0012-1606 (Print) Journal Article; Changes in translatable mRNAs from the wing epidermis of the Coleoptera Tenebrio molitor have been investigated during metamorphosis by analysis of in vitro translated products. Striking differences between the patterns obtained from mRNAs extracted during pupal and adult cuticle secretion indicated that a drastic change in gene expression occurs during the pupal-adult transition. In addition to these stage-specific modifications, the mRNA patterns changed within each cuticular synthesis program (pupal or adult), especially at ecdysis. After tritiated leucine incorporation, some of the major radiolabeled cuticular proteins showed similar changes suggesting…

animal structuresPupa/drug effects/metabolismBiological/*geneticsBiologyMolting cycleWingDNA/*isolation & purificationJuvenile Hormones/*pharmacologyMessenger/*metabolismComplementary DNAGene expressionProtein biosynthesisWings AnimalAnimalsNorthern blotRNA MessengerTenebrioTenebrio/drug effects/*genetics/growth & developmentMolecular BiologyProteins/*geneticsDevelopmental profileMetamorphosisfungiMetamorphosis BiologicalPupaEpidermis/growth & developmentProteinsCell BiologyDNAMolecular biologyJuvenile HormonesEcdysisProtein BiosynthesisJuvenile hormoneInsect ProteinsRNAEpidermisDevelopmental Biology
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Developmental and biochemical studies on the phenylalanine hydroxylation system in Drosophila melanogaster

1992

Abstract The enzyme phenylalanine hydroxylase, the substrate phenylalanine, the product of the reaction tyrosine, and the probable in vivo cofactors (6R)- l -erytro-5,6,7,8-tetrahydrobiopterin (H4Bip) and 5,6,7,8-tetrahydropterin (H4Ptr), have been measured during development in Drosophila. The developmental profile of phenylalanine hydroxylase activity shows two peaks. The larger occurs at the time of pupation, coiciding with an important accumulation of tyrosine in the insect. The minor peak appears at the time of adult emergence. The developmental profile of H4Bip shows also two peaks, coinciding with those of maximal phenylalanine hydroxylase activity. However, H4Ptr is only detectable …

chemistry.chemical_classificationDevelopmental profilebiologyPhenylalanine hydroxylasePhenylalanineTetrahydrobiopterinBiochemistryCofactorHydroxylationchemistry.chemical_compoundEnzymechemistryBiochemistryInsect Sciencebiology.proteinmedicineTyrosineMolecular Biologymedicine.drug
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